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However, some patients report mood changes or anxiety while using this medication, raising important questions about safety and individual response

Last reviewed: July 7, 2026 Last updated: July 7, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

But PEIA had already canceled the obesity-drugs pilot program

Lack of Directionality in Staging Current staging systems do not indicate whether fibrosis is progressing or regressing within a stage, which makes it difficult to assess the true impact of treatment on disease progression4

Some patients have reported using compounded versions of tirzepatide at lower concentrations to facilitate microdosing, though the FDA has issued warnings about the risks of compounded GLP-1 receptor agonists, including concerns about quality, potency, dosing errors, and different salt forms

Sanjay Kalra has received speaker fees from Eli Lilly, Novo Nordisk and Sanofi Aventis