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The epithelium of the gastrointestinal tract is exposed to a variety of trypsin-like proteases that can activate PAR2

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10.1016/j.clinthera.2012.04.013 6 AschnerP.KipnesM

Because if, if one of them is high and then the other one is low, versus both of them are high, if both of them are high, I'm gonna say biopsy I wanna, I want to see both markers