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Cells Tissues Organs, 199 (56), 329341
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Temperatures here can dip below the critical 2C (35.6F) threshold, sometimes reaching 0C or even -1C (32F or 30.2F) , freezing and irreversibly damaging the product
What we do not yet know Critical gaps remain in the evidence base
This activation has been shown to upregulate genes involved in collagen synthesis, cell proliferation, and differentiation while potentially downregulating matrix metalloproteinases
In conclusion, the use of antioxidants in combination with chemotherapeutic agents for cancer therapy may have far-reaching clinical implications, and preclinical exploration coupled with larger multicenter clinical studies are urgently needed in the future to verify the effectiveness of this therapy
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