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A separate ligament study (Cerovecki et al., 2010, Journal of Orthopaedic Research ) reported improved medial collateral ligament healing in rats over 90 days post-transection, with effective dosing observed across intraperitoneal, oral, and topical routes

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They also found that the standard full charge force field (168) overestimates the binding of Ca 2+ ions to carboxylate groups in comparison to the Electronic Continuum Correction (ECC) force field (169)

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