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Whilst effective in improving glycaemic control, gastrointestinal side effects are among the most commonly reported adverse reactions, with constipation affecting a significant proportion of users (classified as 'common' in the SmPC)

Choline (50 mg/mL): Supports fat metabolism and liver function

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Caffeine and alcohol: Both can act as stimulants or irritants to the digestive tract

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The final reduction and discontinuation The transition from 2.5 mg to zero is psychologically the hardest step, even though the pharmacological difference is relatively small