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Although AD-114-Im7-FH PEG 30K had a considerably longer circulation time than the other variants, losses during manufacturing at the PEG conjugation step meant the variant was difficult to produce in quantities required for dosing larger animals, and any additional chromatography steps to obtain homogenous mono-PEGylated material would have further reduced yields

iii) High risk: Three or more criteria rated as unclear or at least two criteria not met

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Scientists often refer to it as the "master antioxidant" because of its central role in cellular protection and detoxification

doi:10.1111/j.1469-8137.1993.tb03863.x

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