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GLP-1 increases glucose-dependent insulin secretion and decreases glucagon secretion after meals

So it is not known if using them causes side effects and how serious they are

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In studies combining NNMTi with other weightloss drugs, coadministration with GLP1 receptor agonists significantly enhances weightloss efficacy while reducing side effects such as nausea and vomiting commonly associated with GLP1 agonists