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Imbalances between glutamate and GABA, which are strongly implicated in neuropsychiatric disorders like MDD [77], can lead to excitotoxicity, whereby excessive glutamate activation of NMDARs and AMPARs triggers calcium overload, oxidative stress, and cell death [78]
Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice
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This change in brain activity was primarily localized to the prefrontal cortex, basal ganglia, thalamus and sensorimotor cortices
