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Nat Rev Cardiol (2026)
Key Insights & Takeaways: 1 A Paradigm Shift Meets Prescriber Inertia: Despite being a first-in-class mechanismapproved in 2024 as the only novel schizophrenia therapy in decadesCOBENFY (xanomeline and trospium chloride) US HCP faces deeply ingrained D2 prescribing habits, as noted by BMS leadership
Human Safety Data Is Minimal A tiny 2025 pilot study testing IV BPC-157 up to 20 mg in 2 healthy adults found it well tolerated with no adverse events and no biomarker changes, but 2 subjects provide essentially zero statistical power
The cells were cultured in Dulbeccos modified Eagles medium (DMEM) supplemented with 10% fetal bovine serum (FBS), 100 g/mL streptomycin, and 100 U/mL penicillin at 37C in a 5% CO2 humidified atmosphere
Some of these, for instance plummeting ultra-processed food sales, might be good
2023;12(19):6216 5 Younossi Z, Aggarwal P, Shrestha J, et al
