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2.2 SURMOUNT study program TZP treatment induced a significant BW reduction in diabetic patients who were obese or overweight

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The SURMOUNT-1 trial showed average weight loss of up to 22.5% of body weight at the highest dose

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The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway