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You may notice: earlier fullness reduced interest in food steadier energy You may not see weight change yet, but these early signals mean its working

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Contact your GP or prescribing clinician if you experience : Severe or worsening fatigue that significantly impairs daily activities or persists beyond several weeks of treatment Extreme weakness or inability to perform usual tasks Dizziness or fainting , particularly on standing, which may indicate dehydration or blood pressure changes Persistent nausea or vomiting preventing adequate food or fluid intake Signs of dehydration : dark urine, reduced urination, dry mouth, confusion Chest pain, palpitations, or breathlessness accompanying tiredness Mood changes , including low mood or depression, which can manifest as fatigue Right upper abdominal pain, fever or yellowing of the skin/eyes , which could indicate gallbladder problems (GLP-1 medications may increase gallstone risk) For urgent but non-emergency concerns, you can contact NHS 111 for advice

And the mucosa contains proteolytic enzymes that present a significant pseudo-first-pass effect for peptide drugs