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Despite being on metformin and glimepiride, his diabetes control has worsened over the past year, with an HbA1c increasing from 7.5% to 8.6%

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in addition, glucagon enhanced the fragility of hepatic lysosomes both mechanically and osmotically and altered sedimentation properties ( GLP-1-Related Autophagy GLP-1RA has been shown to suppress glucagon levels (Mentis et al., 2011)

Controlling diabetes is very important during pregnancy