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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

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Diabetes 59:479485 Schfer SA, Mssig K, Staiger H et al (2009) A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion