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What are the optimal drug characteristics of a GLP-1/glucagon co-agonist for the treatment of NAFLD via hepatic GCGR agonism

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Citations Citations to this article as recorded by Targeting ferroptosis to halt MASLD and MASH Fudi Wang Trends in Endocrinology & Metabolism .2026;[Epub] CrossRef 3,885 View 283 Download 3 Web of Science Crossref Reviews Abstract PDF Metabolic dysfunctionassociated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, has become the most common form of chronic liver disease in children

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Exenatide and lixisenatide are exendin 4-based agents, while albiglutide, dulaglutide, liraglutide, and semaglutide are GLP-1-based agents