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Across all trials, 41 deaths occurred in individuals receiving tirzepatide ( n = 4573) and 39 in the comparator arms ( n = 2151)
This choice was intended to avoid potential confounding associated with non-user comparisons and other active comparators that have been linked to a possible excess risk or decrease in risk of major adverse cardiovascular outcomes 27,47
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You should generally avoid this combination or use extreme caution if you have a history of: Kidney Stones: Topiramate increases the risk of developing kidney stones
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