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The immune system increases blood flow to the injection site, and this reaction produces warmth, swelling and tenderness that form the earliest symptoms

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They release various factors including TNF-, IL-1, IL-6, glutamate, and NO, contributing to oligodendrocyte injury and axonal degeneration

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When growth hormone was added to BPC-157-treated fibroblasts, the researchers observed that cell proliferation increased significantly, and Janus kinase 2 was activated time-dependently (2)