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Contact your GP urgently if you experience: Severe, persistent abdominal pain that does not improve with simple measures or worsens over time Repeated vomiting that prevents you from keeping down fluids or medication Signs of gastrointestinal bleeding , including vomiting blood (haematemesis), coffee-ground vomit, or black, tarry stools (melaena) Symptoms of dehydration such as dizziness, reduced urine output, or extreme thirst, particularly if accompanied by vomiting or diarrhoea Unexplained weight loss beyond the expected therapeutic effect, or loss of appetite that persists beyond the initial weeks of treatment New or worsening dysphagia (difficulty swallowing) Seek immediate medical attention (call 999 or attend A&E) if you develop: Sudden, severe abdominal pain Vomiting large amounts of blood Signs of shock (rapid heartbeat, confusion, cold/clammy skin, rapid breathing) According to NICE guidance (NG12) , urgent referral for suspected upper gastrointestinal cancer (within two weeks) should be considered for: Patients with dysphagia at any age Patients aged 55 and over with weight loss AND upper abdominal pain, reflux or dyspepsia Patients with an upper abdominal mass If gastritis is confirmed through investigation, your healthcare team will work with you to determine whether Wegovy can be continued safely, potentially with additional gastro-protective medication, or whether an alternative weight management approach is more appropriate

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