A recent systematic review of case reports of adverse events linked to GLP-1R agonists highlighted cases of pancreatitis associated with liraglutide and exenatide, although none with semaglutide (47)
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The increase in Akt and ERK phosphorylations lead to cardiomyocyte growth and activation of glucose metabolism [24],[39]-[41]
Furthermore, while some studies failed to identify a significant correlation between GLP-1RA therapy and overall AF, interestingly, they noted that oral semaglutide exerted a potential protective effect against AF, whereas dulaglutide showed an opposing trend (albeit non-robust), with other GLP-1RAs displaying no significant association with AF (134)