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Gutzwiller JP, Tschopp S, Bock A, Zehnder CE, Huber AR, Kreyenbuehl M, Gutmann H, Drewe J, Henzen C, Goeke B, et al: Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men

A 2025 database study published in the International Journal of Impotence Research found that non-diabetic obese men prescribed semaglutide for weight loss had a 4.5-fold higher risk of erectile dysfunction and nearly double the risk of testosterone deficiency compared to matched controls not taking the drug

A combined effect that is bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] In overweight adults aged 45+, a 4-year-long study using semaglutide for weight loss also prevented HbA1c from rising over time, which was seen in the placebo arm

Recommended disposal routes in the UK include: Return to a community pharmacy: Most community pharmacies provide free NHS disposal of unwanted or expired medicines

Sitagliptin binds to the DPP-4 enzyme, preventing the breakdown of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP)

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