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In contrast, even with ongoing neurodegenerative processes, excessive glutamate release on a per-neuron basis, reflected by increased neuronal glutamate concentration, may take place

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But these changes are expected, and theyre biologically driven. Sustaining progress If youre anxious about stopping a GLP-1, ask your doctor if tapering off gradually, taking a lower dose, or using the drug intermittently is a better option (if thats financially possible), Salamon says