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This warning is based on a dose-dependent rodent trial that found that mice exposed to supraphysiologic doses of GLP-1 RAs were more likely to experience C-cell hyperplasia (12, 13)
Furthermore, 65.3% of participants on retatrutide 12 mg achieved a BMI below 30, no longer meeting the criteria for obesity
it also binds to the GIP receptor, offering a dual action mechanism
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These studies illustrate that GLP-1RAs may confer protective effects on the progression of cardiomyopathy [83]
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