Glutathione is the primary antioxidant that protects the mitochondria
Thus, the mutation has survived in the genome in areas where malaria is (or was) prevalent (Africa, Middle East, India, and Southeast Asia)
That chain is too many steps removed from reality to hold up clinically
Although GST affinity materials are commercially available as glutathione immobilized on beaded agarose resins, few simple options for in-house production of those systems exist
This isn't a "jittery" energy like caffeine
In fact, cobalamin deficiency is a common cause of metabolic encephalopathy, one of a number of forms of encephalopathy associated with a primary disease (such as FIP) that causes interference with normal brain function and blood-brain barrier mechanisms