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LncRNA HOTAIR enhances the androgen-receptor-mediated transcriptional program and drives castration-resistant prostate cancer

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Key components include resistance training and daily moderate aerobic exercise, adequate high-quality protein intake (1.21.6 g/kg adjusted body weight/day) distributed evenly across meals, micronutrient supplementation, and periodic reassessment of lean mass via DXA, BIA or functional outcomes (e.g., handgrip strength and gait speed) to optimize fat loss while minimizing sarcopenia risk (Table 2)

A unique fold of phospholipase C- mediates dimerization and interaction with Gq

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