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doi: 10.1016/j.heliyon.2024.e35025

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These simulations indicate that the ECD in the apo-state GLP-1R is quite dynamic and that the TMD-interacting closed conformations are energetically favorable in the absence of the peptide agonist

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As oxidative stress increases, further stimulation of pro-inflammatory cytokines such as TNF- and IL-1 increases and contributes to synaptic dysfunction and neuronal degeneration ( These studies suggest that the loss of antioxidant defense is an early biochemical event rather than a late-stage consequence of neuronal death

National Institute for Health and Care Excellence (2018) Diagnosis of anaemia- B12 and folate deficiency (CKS)