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Bydureon up to 30C for 4 weeks) For opened (in-use) GLP-1 pens: Multi-dose pens (Ozempic, Victoza, Saxenda, Byetta) have specific in-use storage requirements: Ozempic: Up to 6 weeks at temperatures up to 30C or refrigerated Victoza/Saxenda: Up to 1 month at temperatures up to 30C or refrigerated Byetta: Up to 30 days at temperatures up to 25C Write the date of first use on multi-dose pen labels Single-use pens (Wegovy, Trulicity) should be discarded after injection Bydureon must be used immediately after reconstitution Keep the pen cap on when not in use to protect from light Do not store with the needle attached, as this can cause air bubbles, leakage, or contamination Avoid exposure to direct sunlight or heat sources (e.g., radiators, car dashboards) If travelling, store in a cool bag with ice packs (ensure the pen does not come into direct contact with ice) General safety advice: Always inspect the medication before each injection (see next section) Dispose of used pens in a sharps container according to local NHS guidelines If you are unsure whether your pen has been stored correctly, do not use it seek advice from a healthcare professional Keep all medications out of the sight and reach of children Patients should familiarise themselves with the specific storage instructions for their prescribed GLP-1 product, as requirements vary significantly between brands

The thought is that the GLP-1 agonists mechanism of action can lead to pancreatic cell hyperplasia (since the GLP-1 receptors are in the islet beta cells and exocrine duct cells), leading to a back up in pressureand you got it, inflammation

Individualized care remains essential as well

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Beyond kidney outcomes, semaglutide was associated with lower risk for major CV events and all-cause mortality compared with placebo (Graphic)