Whilst study findings seem to not support folate genotype being selected to enhance DNA repair pathways in high UVR environments, the relationship between UVR and folate is proposed to have a role in strengthening our epidermal barrier
introducing high doses of glutathione too rapidly can occasionally trigger a "Herxheimer" or detoxification reaction, where the sudden mobilization of stored toxins temporarily exacerbates symptoms like fatigue, brain fog, or mild nausea
AA Jackson, NR Gibson, Y Lu, F Synthesis of erythrocyte glutathione in healthy adults consuming the safe amount of dietary protein.Am J Clin Nutr
Nrf2 is a multifunctional transcription factor that plays an important role in the antioxidant process (Shen et al., 2019)
But due to the following factors, its levels deplete in the body: Stress Medication and Drugs Pollution Poor Diet Toxin buildup leading to increased oxidative stress Aging Keeping in mind the lifestyle of metrocities that includes poor diet, sleep and even habits like smoking and occasional alcohol consumption, Glutathione levels suffer in the process of upkeep and neutralising of free radicals
These observations suggest the peptides benefits extend beyond local tissue effects to systemic regulatory improvements