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When joints are inflamed, they produce excess reactive oxygen species (ROS), which include superoxide and hydrogen peroxide, to the point that they overwhelm the bodys defences and deplete the local glutathione supply [6]
Methods THP-1 and J774A.1 macrophage cell lines were activated with TLR4 (LPS) or TLR2 (Pam3CSK4) agonists and treated with BSFL oil or purified C12:0
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In one of these studies, measuring brain GSH levels with in vivo proton MRS yielded a correlation in GSH reduction and decline in cognitive functions with 87.5% sensitivity and 100% specificity (Mandal et al., 2015)
