There is no crash, no jitters, and no dependency
Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13
Its all about listening to your body and adjusting your plan based on how you feel and how your levels respond to treatment
Rare but serious side effects include allergic reactions
Last clinically reviewed: 31 July 2026 Clinical information sources NICE NG239 Vitamin B12 deficiency in over 16s: diagnosis and management NHS Vitamin B12 or folate deficiency anaemia NHS Diagnosis NHS Treatment MHRA Vitamin B12 and cobalt allergy advice This page provides general information about the pharmacy service and does not replace personalised advice from a pharmacist, GP or other healthcare professional
Improves insulin resistance in older individuals, increases mobility for people with peripheral artery disease and reduces symptoms of Parkinson's disease