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The nitroimidazole prodrug Evofosfamide (TH-302) [493,494,495,496] releases alkylating agents upon reductive cleavage while concomitantly producing cytotoxic free radicals, synergistically exacerbating local oxidative damage

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Enteroendocrine localization of GLP-2 receptor expression in humans and rodents

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PT-141 was engineered for improved selectivity toward MC4R with reduced MC1R activity, eliminating the tanning effect while retaining central arousal pathway activity