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Berberine is classified as a dietary supplement rather than a prescription medication, and formal clinical studies evaluating this specific combination are lacking

On non-training days, take your dose in the morning on an empty stomach for better absorption

Regulation of Met metabolism in the liver In the liver, when the consumption of Met exceeds its average dietary intake, de novo synthesis of Met occurs via the transfer of a methyl group from methylene-THF first by methylene-THF reductase (MTHFR) and then by Met synthase (MS) to Hcy to form Met to make up the difference (Figure 2)

Easing in by including foods like honey, squash, and cucumber (low in lectins and oxalates) can also help