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There is a strong recommendation not to combine DPP-4 inhibitors with GLP-1 receptor agonists, and DPP-4 inhibitor therapy should be discontinued when treatment is escalated with an injectable therapy at later stages with a GLP-1 receptor agonist (7072)
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New England Journal of Medicine , 389(6), 514526
Risks increase with underdosed or impure research-grade products and improper administration
Inhibition of GPX4 or its upstream factors can induce ferroptosis
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