For those looking to significantly raise their levels for specific health goals, high-quality supplementation is usually necessary.
Beyond gastrointestinal effects, clinicians should monitor for several less common but clinically significant adverse events
Whereas ultra-high (25mg daily for 4 weeks) intramuscular doses of methylcobalamin (a form of vitamin B12) have been shown to slow muscle wasting (Izumi 2007), low levels of vitamin B12 have been associated with nerve damage in many different animal models
Whalen KL, Lerchenfeldt SM, Giordano CR (Editors)
Lethargy and reduced energy peak 24 hours post-dose, which is why nighttime administration is standard
A 10 mg total vial is a research-practical size: enough for substantial protocols, small enough to consume within the reconstituted-stability window for most research designs