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Thyroid function was monitored, and no clinically meaningful changes in thyroid parameters were attributed to semaglutide in participants without pre-existing thyroid conditions (Wilding et al., 2021, NEJM )

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Extending Melanotan-1 cycle length beyond 12 weeks does not increase adverse event risk because melanogenesis reaches equilibrium at 810 weeks continued dosing maintains pigmentation without further deepening

Do not double up to compensate, as this defeats the purpose of split dosing and creates the same high peak you were trying to avoid

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