For drug developers, laboratory developed tests (LDT) could open up opportunities for more precise patient stratification, improving the probability of success in clinical trials evaluating the expansion of GLP-1 drugs into new indications
Its cellular-level mechanism appeals to those wanting to optimize metabolic function rather than override it
Some of the drugs have also been associated with improvements in peripheral artery disease and symptoms of heart failure with preserved ejection fraction
10.1038/onc.2017.38 Summary Keywords alcohol-associated liver disease (ALD), glucagon-like peptide 1 receptor agonists (GLP-1 RAs), metabolic dysfunction and alcohol-associated liver disease (MetALD), metabolic dysfunction-associated steatotic liver disease (MASLD), steatotic liver disease (SLD) Citation Mahalingam S, Kharbanda KK, Casey CA and Rasineni K (2026) Beyond diabetes and obesity: GLP-1 receptor agonists as multifunctional therapeutics across the steatotic liver disease spectrum
Results Demographic and clinical characteristics of all participants In total, 494 participants (mean age: 43 years, 71.05% male) were enrolled in this study (Table 1)