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UV radiation can excite skin cells, resulting in the generation of ROS such as singlet oxygen (1O2) and superoxide radicals [53]

PubMed Martinez E, Domingo P, Roca-Cusachs A

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In addition, HGF promotes the phosphorylation of STAT3 to activate the STAT3 pathway ( The PI3K/Akt pathway plays a vital role in regulating cell growth, migration, differentiation, and apoptosis (Vanhaesebroeck et al., 1999)