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Participants were randomly assigned to receive retatrutide (4 mg, 9 mg, or 12 mg) or placebo by once-weekly subcutaneous injection (134, 133, 136, and 134 individuals, respectively).The researchers found that for the treatment regimen estimand, the mean change from baseline in hemoglobin A1c concentration was 1.69, 1.86, and 1.94 percent with 4, 9, and 12 mg of retatrutide, respectively, versus 0.81 percent with placebo, resulting in estimated treatment differences of 0.88, 1.04, and 1.12 percent, respectively, versus placebo

Adequate fat intake supports hormone production and satiety

Targets nicotinamide N-methyltransferase (NNMT)

"The induction effect of efavirenz persists for at least 2 weeks after stopping drug intake

Fatigue: Some individuals report feeling more tired than usual