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Interestingly, the rise in hormone-sensitive lipase (HSL) phosphorylation within cardiac myocytes appears to rely on a GIPR-mediated increase in ERK phosphorylation

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Retatrutide appeared to induce lean mass loss in similar proportions to GLP-1RAs alone, whereas PTT-A has shown robust fat reduction without significant decrease in muscle mass, highlighting the potential of selective multi-agonists to preserve skeletal muscle during weight loss [66, 67]

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