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Acknowledgements We thank Jean-Yves Masson and Hongtao Yu for generously providing plasmids for various PDS5B constructs

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Importantly, as shown in the first row, LASSS supplementation effectively prevented an increase in the nitration level of ECM-HGF, whereas GSSSG did not demonstrate efficacy, inconsistent with its potent potential shown in in vitro experiments described earlier (see Figure 1b)