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Persistent unexplained elevation alongside an abnormal CBC or differential, constitutional symptoms such as unexplained weight loss, night sweats, or persistent fever, or organ-specific findings all raise the need for referral

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Endotoxin screening Endotoxins are inflammatory bacterial components that may remain even when a product appears clean

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All of the treatments discussed above may improve the prognosis of neonatal HIBD through the target of neurogenesis