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Inside this ligation complex, XRCC4 directly interacts with DNA ligase IV (Lig4) and stimulates break rejoining catalysis 9,10,11

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DNA coding for the DPP-4 resistant GLP-1 analogue peptide in fusion with the [G 4 S] 3 A or GGSA amino acid linker, as well as for exendin-4 peptide in fusion with the [G 4 S] 3 A linker, were also synthesized by GeneArt

Research-Studied Effects The primary focus of research on this combination is the so-called dual signaling mechanism