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The glycine benefits operate on different timelines: mTOR-mediated muscle protection begins immediately at the cellular level, glutathione synthesis improvement occurs within days, anti-inflammatory effects manifest within 1-2 weeks, and sleep quality improvements (if glycine is also taken orally) often appear within the first week

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PARP-1 contributes significantly by selectively binding to cisplatin-induced DNA damage, particularly 1, 2-d(GpG) crosslinks ( Table 4 )

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