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Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025

Folate also directs cysteine to glutathione production and away from homocysteine production

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Moreover, these treatments are typically administered in unregulated, informal settings, with little regard for medical standards or safety protocols

Poliosis itself is not harmful

1 2 Food and Drug Administration (FDA) (14 October 2010)