we call this the ileal brake system , and it is at the heart of managing blood sugar, appetite, and metabolic efficiency
Interestingly, the aryl hydrocarbon receptor (AhR) of the tryptophan-kynurenine pathway serves as a critically important mediator between tryptophan metabolism, immune reactions, and tissue homeostasis (4143), and several kynurenine metabolites have been associated with fatigue (44, 45)
Tirzepatide Pros: In addition to acting as a GLP1 agonist, there is GIP agonism which means it works on two pathways to aid in weight loss
However, the length of time may be adjusted based on how well the treatment works for the individual and whether any side effects are experienced
SURPASS-4 extended into T2D adults at increased CV risk versus insulin glargine (PMID 34672967)
Hillis GS, Hata J, Woodward M, Perkovic V, Arima H, Chow CK, Zoungas S, Patel A, Poulter NR, Mancia G, Williams B, Chalmers J