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The substantial increase in plasma bile acid concentrations (primary, secondary, total and unconjugated bile acid concentrations) with metformin may be explained by the fact that metformin increased the abundance of probiotic bacteria, especially Lactobacillus , and thus their bile salt hydrolase (BSH) gene expression
Conjugation with glutathione receptors renders toxic substances more soluble, and therefore more readily exocytosed from the cell
Both substances have diuretic effects that worsen dehydration and can stimulate intestinal motility
Hair operates on long growth cycles, so visible improvements take time
For patients, this represents meaningful progress