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Safety Outcomes Proportion of Patients Experiencing Nausea, Vomiting, and Diarrhoea All six trials reported the proportion of patients experiencing nausea, vomiting, and diarrhoea (any grade permitted) at week 40 (tirzepatide) and week 26 ( 4 weeks) (comparators)

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Approximately 5-10% of patients experience prolonged symptoms that don't follow the typical resolution curve

The SELECT trial (Lincoff and colleagues) of semaglutide in overweight or obese adults with established cardiovascular disease but without diabetes found a 20% reduction in major heart events

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