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For male mice, we defined 36 min as a hard ischaemia dose (Figs
In epilepsy research, although there are several reports illustrating that enhancement of GABA-mediated inhibitory neurotransmission [139] and ion channel inhibition [140] are involved in the convulsive effects of VPA, there is also prior work supporting that HDACs serve as vital upstream regulators of molecular targets associated MoAs such as ion channel [164]
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