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CYP3A4, CYP2D6, CYP1A2, and CYP2C9 are the primary isoforms, collectively metabolizing up to 80% of all pharmaceutical drugs (Annual Review of Pharmacology and Toxicology, 2018)

Try to cut down on: Energy drinks Excessive cups of coffee (more than 23 per day) Strong black tea in large amounts Dairy (If Not Tolerated) Milk and cheese can cause inflammation and stomach stress in people who are sensitive to them

Suggested Use: Take one capsule daily

Communication with the prescribing clinician is essential before making any dose adjustments, as this may affect glycemic control or weight management outcomes

176 The 2020 KDOQI guidelines recommend that adults with stage 35 CKD limit dietary phosphorus intake to maintain normal blood phosphate levels (2.54.5 mg/dL)

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