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By enhancing HGF activity, Dihexa may promote new synapse formation and improve neural network function

(PubMed) George JD, Kim E, Spain R, Bourdette D, Salinthone S

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10.1016/j.freeradbiomed.2022.12.086 10 CaoJ

Trehalose activates TFEB and enhances autophagic clearance of tau and -synuclein in AD and PD models

However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind