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26 From a bioenergetics angle, the GLP-1 response is highly inefficient (GLP-1 synthesis requires ATP), due to the majority of the GLP-1 secreted being inactivated before it reaches its targets

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Liraglutide, a long-acting human glucagon-like Peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes

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