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In March 2024, the FDA expanded Wegovys approval to include reducing cardiovascular risk in people with obesity and existing cardiovascular diseasea major milestone for these treatments
10.3390/ijms24054490 104 TieuS.CharchoglyanA.PaulsenL.Wagter-LesperanceL
In the first two studies, changes in redox and methylation metabolism were reported but because the studies were open-label the changes in these biomarkers were not compared to a placebo group
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Knowing the regulatory foundation, safety profile, and how personalization can support your provider's decision-making empowers you to have a more informed conversation about treatment options
Both compounds are contraindicated in pregnancy and should be discontinued well before planned conception due to their effects on nutrient absorption and fetal development
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